Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | DRD3 | P35462 | 7/20 | 0.53 |
| ▸ | HTR2B | P41595 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 6/20 | 0.53 |
| ▸ | HRH1 | P35367 | 6/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983077 | 0.93 | HTR7 (0.57) | HTR7HTR1ADRD2DRD3HTR2B | |
| SCHEMBL2822684 | 0.78 | PARP1 (0.37) | PARP2PARP1HDAC8HDAC2 | |
| SCHEMBL2977065 | 0.75 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL3891857 | 0.72 | HDAC3 (0.68) | HTR7HTR1ADRD2DRD3HTR2B | |
| SCHEMBL2981868 | 0.72 | GAA (0.47) | KDM4E | |
| SCHEMBL2977670 | 0.71 | GRIN2B (0.39) | OPRM1OPRD1OPRK1 | |
| SCHEMBL4229925 | 0.71 | HTR7 (0.73) | HTR7HTR1ADRD2DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL4251907 | 0.71 | HDAC3 (0.67) | HTR7HTR1ADRD2DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL4222979 | 0.70 | HTR7 (0.71) | HTR7HTR1ADRD2DRD3HTR2B | |
| SCHEMBL4225894 | 0.70 | HDAC3 (0.71) | HTR7HTR1ADRD2DRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781435-B2 | Imidazole compounds for the treatment of neurological disorders | PFIZER INC (US) | 2010-08-24 | — | — | US | claimed |
| US-20070066613-A1 | Imidazole compounds for the treatment of neurological disorders | PFIZER INC | 2007-03-22 | — | — | US | claimed |
| US-7781435-B2 | Imidazole compounds for the treatment of neurological disorders | PFIZER INC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20100184737-A1 | IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | PFIZER INC (US) | 2010-07-22 | — | — | US | disclosed |
| US-20070066613-A1 | Imidazole compounds for the treatment of neurological disorders | PFIZER INC | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066613-A1 | Imidazole compounds for the treatment of neurological disorders | APP, PSEN1, BACE1 | HTR7 768/4885HTR1A 384/4885DRD2 1020/4885 |
| US-20100184737-A1 | IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | APP, PSEN1, BACE1 | HTR7 768/4885HTR1A 384/4885DRD2 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.