Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.33 |
| ▸ | TDO2 | P48775 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20211877 | 1.00 | KDM1A (0.34) | KDM1AKCNH2TRIM24TRIM33KDM1B | |
| Hydrochloric Acid SCHEMBL17870558 | 0.77 | ALDH1A1 (0.45) | KDM1AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1814706 | 0.77 | NOTUM (0.50) | TRIM24TRIM33NOTUMALDH1A1KDM4E | |
| SCHEMBL20231015 | 0.77 | TRIM24 (0.44) | TRIM24TRIM33KMT2AALDH1A1KDM4E | |
| SCHEMBL29683585 | 0.76 | MEN1 (0.39) | KDM1AKCNH2KDM1BNOTUMMEN1 | |
| SCHEMBL20211863 | 0.76 | MEN1 (0.39) | KDM1AKCNH2KDM1BNOTUMMEN1 | |
| Hydrochloric Acid SCHEMBL1818467 | 0.76 | NOTUM (0.49) | TRIM24TRIM33NOTUMALDH1A1KDM4E | |
| SCHEMBL28867024 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29937495 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL25437324 | 0.75 | BPTF (0.52) | MEN1KMT2AALDH1A1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118834201-A | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degrading agents | 阿尔维纳斯运营股份有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-110291087-B | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degrading agents | 阿尔维纳斯运营股份有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-114656452-B | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders | 阿尔维纳斯运营股份有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114656452-A | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders | 阿尔维纳斯运营股份有限公司 | 2022-06-24 | — | — | CN | disclosed |