Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23757942 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2TRPV3L3MBTL1EPHX2POLB | |
| SCHEMBL23757943 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2TRPV3L3MBTL1EPHX2POLB | |
| Hydrochloric Acid SCHEMBL29686210 | 0.99 | SMN1; SMN2 (0.38) | SMN1; SMN2TRPV3L3MBTL1EPHX2POLB | |
| SCHEMBL23757461 | 0.86 | CASR (0.31) | — | |
| SCHEMBL30025226 | 0.86 | CASR (0.31) | — | |
| SCHEMBL23757269 | 0.84 | HTT (0.36) | SMN1; SMN2POLB | |
| SCHEMBL23757267 | 0.84 | HTT (0.36) | SMN1; SMN2POLB | |
| SCHEMBL23757646 | 0.84 | ADRB2 (0.32) | — | |
| SCHEMBL23757520 | 0.84 | ADRB2 (0.32) | — | |
| SCHEMBL23757802 | 0.84 | ADRB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | Amgen, Inc (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-4103558-A1 | NOVEL PRMT5 INHIBITORS | Amgen Inc. (US) | 2022-12-21 | — | — | EP | disclosed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |