SCHEMBL29686381

SCHEMBL29686381

CC(C)n1cnc2c(NCCc3ccc(O)cc3)nc(-c3csc4ccccc34)nc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AHR P35869 1/20 1.00
▸ CDK1 P06493 13/20 0.47
▸ CCNB1 P14635 9/20 0.47
▸ CCNB2 O95067 8/20 0.47
▸ CCNB3 Q8WWL7 8/20 0.47
▸ CDK2 P24941 6/20 0.45
▸ CCNE1 P24864 4/20 0.45
▸ CCNE2 O96020 2/20 0.45
▸ CCNA2 P20248 2/20 0.45
▸ CCNA1 P78396 2/20 0.45
▸ CCNK O75909 1/20 0.44
▸ CDK12 Q9NYV4 1/20 0.44
▸ TDP1 Q9NUW8 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ CDK5 Q00535 6/20 0.42
▸ CSNK1D P48730 1/20 0.42
▸ CLK2 P49760 1/20 0.42
▸ DYRK1A Q13627 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2314094 1.00 AHR (1.00) AHRCDK1CCNB1CCNB2CCNB3
Hydrochloric Acid SCHEMBL15422822 0.99 AHR (0.98) AHRCDK1CCNB1CCNB2CCNB3
Hydrochloric Acid SCHEMBL31615007 0.99 AHR (0.98) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL2315208 0.93 AHR (0.87) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL15011335 0.93 AHR (0.87) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL2317306 0.92 AHR (0.85) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL19766270 0.92 AHR (0.85) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL2311353 0.91 AHR (0.84) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL2315457 0.91 AHR (0.83) AHRCDK1CCNB1CCNB2CCNB3
SCHEMBL2314087 0.91 AHR (0.83) AHRCDK1CCNB1CCNB2CCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025024849-A1 COMPOSITIONS AND METHODS OF MAKING AND USING IPSC-DERIVED CAR MACROPHAGES CITY OF HOPE (US) 2025-01-30 — — WO claimed
CN-110546262-B Compositions and methods for treating hemoglobinopathies 诺华股份有限公司 2024-08-02 — — CN claimed
EP-3362075-B1 NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF CELULARITY INC (US) 2023-06-07 — — EP claimed
CN-115176005-A Compositions and methods for treating hemoglobinopathies 诺华股份有限公司 2022-10-11 — — CN claimed
EP-4743096-A1 BIOBANK OF CELLULAR BANKS HAVING SPECIFIC HOMOZYGOUS HLA HAPLOTYPES AND USES THEREOF FOR TREATING PATIENTS Meiragtx Cell Therapies (FR) 2026-05-20 — — EP disclosed
WO-2025199576-A1 HAEMATOPOIETIC STEM/PROGENITOR CELLS AND METHODS FOR THEIR PRODUCTION MURDOCH CHILDREN'S RESEARCH INSTITUTE (AU) 2025-10-02 — — WO disclosed
US-20250043311-A1 MICROSPHERE FACILITATED INTRACELLULAR DELIVERY AND ASSOCIATED METHODS AND DEVICES VisiCELL Medical Inc. (US) 2025-02-06 — — US disclosed
WO-2025024849-A1 COMPOSITIONS AND METHODS OF MAKING AND USING IPSC-DERIVED CAR MACROPHAGES CITY OF HOPE (US) 2025-01-30 — — WO disclosed
WO-2025012449-A1 BIOBANK OF CELLULAR BANKS HAVING SPECIFIC HOMOZYGOUS HLA HAPLOTYPES AND USES THEREOF FOR TREATING PATIENTS SMART IMMUNE (FR) 2025-01-16 — — WO disclosed
CN-119286853-A Compositions and methods for treating hemoglobinopathies 诺华股份有限公司 2025-01-10 — — CN disclosed
CN-119193710-A Reduced and minimal manipulation of genetically modified cells 弗莱德哈钦森癌症中心 2024-12-27 — — CN disclosed
US-12173320-B2 Production of red blood cells and platelets from stem cells BOSTON MEDICAL CENTER CORPORATION (US) 2024-12-24 — — US disclosed
EP-3362075-B1 NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF CELULARITY INC (US) 2023-06-07 — — EP disclosed
EP-3524604-B1 EXPANDED HEMATOPOIETIC STEM CELLS FROM CORD BLOOD AND THEIR THERAPEUTIC USE NOVARTIS AG (CH) 2023-03-29 — — EP disclosed
WO-2023034941-A1 MICROSPHERE FACILITATED INTRACELLULAR DELIVERY AND ASSOCIATED METHODS AND DEVICES VisiCELL Medical Inc. (US) 2023-03-09 — — WO disclosed
WO-2022269518-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES NOVARTIS AG (CH) 2022-12-29 — — WO disclosed
EP-4096688-A1 NATURAL KILLER CELLS FOR TREATMENT OF CORONAVIRUS INFECTION Sorrento Therapeutics, Inc. (US) 2022-12-07 — — EP disclosed
EP-4077676-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES Novartis AG (CH) 2022-10-26 — — EP disclosed
CN-115176005-A Compositions and methods for treating hemoglobinopathies 诺华股份有限公司 2022-10-11 — — CN disclosed
US-20220177845-A1 PRODUCTION OF RED BLOOD CELLS AND PLATELETS FROM STEM CELLS BOSTON MEDICAL CENTER CORPORATION 2022-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12173320-B2 Production of red blood cells and platelets from stem cells AHR, CD14, MPL AHR 1/4885CDK1 3533/4885CCNB1 3834/4885
US-20220177845-A1 PRODUCTION OF RED BLOOD CELLS AND PLATELETS FROM STEM CELLS AHR, CD14, MPL AHR 1/4885CDK1 3533/4885CCNB1 3834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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