SCHEMBL29686555

SCHEMBL29686555

CCn1nc(C)cc1C(=O)Nc1nc2cc(C(N)=O)cnc2[nH]1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 20/20 0.53
TBK1 Q9UHD2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29626030 0.84 STING1 (0.60) STING1TBK1
SCHEMBL28720810 0.84 STING1 (0.60) STING1TBK1
SCHEMBL21789703 0.83 STING1 (0.52) STING1TBK1
SCHEMBL30084070 0.82 STING1 (0.58) STING1TBK1
SCHEMBL29675240 0.81 STING1 (0.63) STING1
SCHEMBL25831201 0.81 STING1 (0.63) STING1
Hydrochloric Acid SCHEMBL31066892 0.80 STING1 (0.62) STING1
SCHEMBL29899007 0.79 STING1 (0.65) STING1
Trifluoroacetic Acid SCHEMBL28606482 0.78 STING1 (0.54) STING1TBK1
SCHEMBL30803059 0.78 STING1 (0.57) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022246597-A1 IMIDAZOPYRIDINE DERIVATIVES AS STING AGONISTS FOREVER MILLETS LIMITED (CN) 2022-12-01 WO disclosed
CN-114585623-A Bis [ N- ((5-carbamoyl) -1H-benzo [ d ] imidazol-2-yl) pyrazole-5-carboxamide ] derivatives and related compounds as STING (interferon gene stimulator) agonists for the treatment of cancer 梅尔莎纳医疗公司 2022-06-03 CN disclosed