Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20240859 | 1.00 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL30590299 | 1.00 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL20240836 | 0.89 | POLB (0.39) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL29688628 | 0.89 | POLB (0.39) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL20243515 | 0.86 | AKR1C3 (0.44) | CYP11B1CYP11B2PIK3CDACLY | |
| SCHEMBL29688594 | 0.86 | AKR1C3 (0.44) | CYP11B1CYP11B2PIK3CDACLY | |
| SCHEMBL29688933 | 0.85 | KDM4E (0.41) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL20254635 | 0.85 | KDM4E (0.41) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL20240823 | 0.83 | PIK3CD (0.37) | CYP11B1CYP11B2CYP17A1CYP3A4PIK3CD | |
| SCHEMBL14753989 | 0.80 | PIK3CD (0.47) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267959-B | Imidazo [1,5-A ] pyrazine derivatives as PI3K delta inhibitors | 百济神州有限公司 | 2022-05-27 | — | — | CN | disclosed |