Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20243515 | 1.00 | AKR1C3 (0.44) | AKR1C3AKR1C2PIK3CDEGFRFGFR1 | |
| SCHEMBL29688422 | 0.86 | CYP11B1 (0.39) | PIK3CDACLYCYP11B1CYP11B2 | |
| SCHEMBL20240859 | 0.86 | CYP11B1 (0.39) | PIK3CDACLYCYP11B1CYP11B2 | |
| SCHEMBL30590299 | 0.86 | CYP11B1 (0.39) | PIK3CDACLYCYP11B1CYP11B2 | |
| SCHEMBL29688628 | 0.85 | POLB (0.39) | PIK3CDCYP11B1CYP11B2 | |
| SCHEMBL20240836 | 0.85 | POLB (0.39) | PIK3CDCYP11B1CYP11B2 | |
| SCHEMBL29688687 | 0.81 | LMNA (0.46) | ACLYMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL20255018 | 0.81 | LMNA (0.46) | ACLYMKNK1MKNK2CYP11B1CYP11B2 | |
| SCHEMBL29688655 | 0.81 | PIK3CD (0.38) | PIK3CDEGFRFGFR1KDRACLY | |
| SCHEMBL20254650 | 0.81 | PIK3CD (0.38) | PIK3CDEGFRFGFR1KDRACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267959-B | Imidazo [1,5-A ] pyrazine derivatives as PI3K delta inhibitors | 百济神州有限公司 | 2022-05-27 | — | — | CN | disclosed |