Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533501 | 1.00 | POLB (0.76) | POLBALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL2010056 | 0.86 | POLB (1.00) | POLBALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL4003419 | 0.86 | ALDH1A1 (0.69) | POLBALDH1A1MAPTMEN1NPC1 | |
| SCHEMBL9300058 | 0.86 | ALDH1A1 (0.59) | POLBALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL11667316 | 0.84 | NPC1 (0.59) | POLBALDH1A1GAAMAPTALOX15 | |
| SCHEMBL4004962 | 0.84 | POLB (0.54) | POLBALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL13662282 | 0.83 | POLB (0.79) | POLBALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL10741819 | 0.82 | POLB (0.50) | POLBALDH1A1GAAMAPTHDAC3 | |
| SCHEMBL5866568 | 0.82 | ALDH1A1 (0.52) | POLBALDH1A1RAB9AKMT2ANPSR1 | |
| SCHEMBL2639130 | 0.81 | POLB (0.76) | POLBALDH1A1GAAMAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116963733-A | Imidazole compounds as ENPP1 inhibitors | 斯汀格瑞治疗股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| EP-4255425-A1 | IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1 | Stingray Therapeutics, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022119928-A1 | IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1 | Stingray Therapeutics, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |