Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26962403 | 1.00 | GPR3 (0.45) | GPR3SRD5A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2166284 | 0.82 | GPR3 (0.45) | GPR3 | |
| SCHEMBL2166290 | 0.82 | GPR3 (0.45) | GPR3 | |
| SCHEMBL31207903 | 0.82 | GPR3 (0.45) | GPR3CYP19A1CYP11B1CYP11B2HTR1A | |
| SCHEMBL25433484 | 0.82 | GPR3 (0.45) | GPR3CYP19A1CYP11B1CYP11B2HTR1A | |
| SCHEMBL25433489 | 0.82 | GPR3 (0.45) | GPR3CYP19A1CYP11B1CYP11B2HTR1A | |
| SCHEMBL1876278 | 0.82 | GPR3 (0.45) | GPR3 | |
| SCHEMBL2166282 | 0.82 | GPR3 (0.45) | GPR3 | |
| SCHEMBL2166554 | 0.82 | GPR3 (0.45) | GPR3 | |
| SCHEMBL2166549 | 0.82 | GPR3 (0.45) | GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116848107-A | Compounds and their use as PDE4 activators | 米罗尼德有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-114539257-B | Pyrimidine diketone spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-114539257-A | Pyrimidinedione spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |