Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 13/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23012955 | 1.00 | NLRP3 (0.51) | NLRP3PTGDR2PDE4APDE4CPDE4D | |
| SCHEMBL29691373 | 0.81 | NLRP3 (0.47) | NLRP3CTSA | |
| SCHEMBL23012726 | 0.81 | NLRP3 (0.47) | NLRP3CTSA | |
| SCHEMBL22774290 | 0.79 | NLRP3 (0.58) | NLRP3PTGDR2CTSA | |
| SCHEMBL29691524 | 0.79 | NLRP3 (0.58) | NLRP3PTGDR2CTSA | |
| SCHEMBL22773915 | 0.79 | NLRP3 (0.54) | NLRP3PTGDR2 | |
| Trifluoroacetic Acid SCHEMBL30163206 | 0.79 | NLRP3 (0.54) | NLRP3PTGDR2CTSA | |
| SCHEMBL22866622 | 0.78 | NLRP3 (0.55) | NLRP3PTGDR2 | |
| SCHEMBL22802350 | 0.78 | NLRP3 (0.35) | NLRP3 | |
| SCHEMBL22773925 | 0.76 | NLRP3 (0.57) | NLRP3PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013762-A1 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | Inflazome Limited (IE) | 2022-06-22 | — | — | EP | disclosed |
| CN-114555609-A | Macrocyclic sulfonamide derivatives useful as NLRP3 inhibitors | 英夫拉索姆有限公司 | 2022-05-27 | — | — | CN | disclosed |