Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 6/20 | 0.45 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
| ▸ | NOTCH3 | Q9UM47 | 3/20 | 0.39 |
| ▸ | CCKBR | P32239 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15622047 | 1.00 | NOTCH1 (0.45) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL22455443 | 1.00 | NOTCH1 (0.45) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL15622200 | 1.00 | NOTCH1 (0.45) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL17030708 | 0.90 | NOTCH1 (0.42) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL17030683 | 0.88 | NOTCH1 (0.40) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL17030706 | 0.86 | NOTCH1 (0.43) | NOTCH1RBPJNOTCH3CCKBRCCKAR | |
| SCHEMBL15622296 | 0.86 | NOTCH1 (0.47) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL17019559 | 0.86 | NOTCH1 (0.47) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL15623736 | 0.84 | NOTCH1 (0.46) | NOTCH1RBPJGABRA1GABRA5GABRA3 | |
| SCHEMBL17030690 | 0.84 | GABRA1 (0.45) | NOTCH1GABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787155-B | Pharmaceutical compounds | 辉瑞公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-114555604-B | Pharmaceutical compounds | 辉瑞公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-114761397-B | Benzodiazepine derivatives for the treatment of Respiratory Syncytial Virus (RSV) infection | 辉瑞公司 | 2024-11-05 | — | — | CN | disclosed |
| EP-4051675-A1 | PHARMACEUTICAL COMPOUNDS | Reviral Limited (GB) | 2022-09-07 | — | — | EP | disclosed |
| WO-2022180397-A1 | BENZODIAZEPINES FOR TREATING OR PREVENTING RESPIRATORY SYNCYTIAL VIRUS INFECTION | ReViral Limited (GB) | 2022-09-01 | — | — | WO | disclosed |
| EP-4017856-A1 | PHARMACEUTICAL COMPOUNDS | Reviral Limited (GB) | 2022-06-29 | — | — | EP | disclosed |