Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.82 |
| ▸ | KDR | P35968 | 7/20 | 0.82 |
| ▸ | AXL | P30530 | 6/20 | 0.82 |
| ▸ | KIT | P10721 | 6/20 | 0.82 |
| ▸ | FLT3 | P36888 | 6/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.82 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.82 |
| ▸ | EGFR | P00533 | 3/20 | 0.82 |
| ▸ | RET | P07949 | 2/20 | 0.82 |
| ▸ | FLT1 | P17948 | 2/20 | 0.82 |
| ▸ | MST1R | Q04912 | 2/20 | 0.82 |
| ▸ | FLT4 | P35916 | 2/20 | 0.82 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.82 |
| ▸ | PLK4 | O00444 | 2/20 | 0.82 |
| ▸ | AURKA | O14965 | 2/20 | 0.82 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.82 |
| ▸ | STK10 | O94804 | 2/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.82 |
| ▸ | FYN | P06241 | 2/20 | 0.82 |
| ▸ | YES1 | P07947 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371897 | 1.00 | MET (0.82) | METKDRAXLKITFLT3 | |
| SCHEMBL371758 | 0.97 | MET (0.87) | METKDRAXLKITFLT3 | |
| SCHEMBL29693418 | 0.97 | MET (0.87) | METKDRAXLKITFLT3 | |
| SCHEMBL19373347 | 0.95 | MET (0.75) | METKDRAXLKITFLT3 | |
| SCHEMBL29693403 | 0.95 | MET (0.83) | METKDRAXLKITFLT3 | |
| SCHEMBL371625 | 0.95 | MET (0.83) | METKDRAXLKITFLT3 | |
| SCHEMBL372124 | 0.93 | MET (0.87) | METKDRAXLKITFLT3 | |
| SCHEMBL29693430 | 0.93 | MET (0.87) | METKDRAXLKITFLT3 | |
| SCHEMBL20525847 | 0.91 | MET (0.83) | METKDRAXLKITFLT3 | |
| SCHEMBL371891 | 0.91 | MET (0.83) | METKDRAXLKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | claimed |