Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.79 |
| ▸ | KDR | P35968 | 8/20 | 0.79 |
| ▸ | AXL | P30530 | 7/20 | 0.79 |
| ▸ | RET | P07949 | 3/20 | 0.78 |
| ▸ | KIT | P10721 | 3/20 | 0.78 |
| ▸ | FLT3 | P36888 | 3/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.76 |
| ▸ | MERTK | Q12866 | 5/20 | 0.73 |
| ▸ | FLT1 | P17948 | 3/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.73 |
| ▸ | AURKA | O14965 | 2/20 | 0.73 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.73 |
| ▸ | ABL1 | P00519 | 2/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372083 | 1.00 | MET (0.79) | METKDRAXLRETKIT | |
| SCHEMBL371775 | 1.00 | MET (0.79) | METKDRAXLRETKIT | |
| SCHEMBL29693434 | 1.00 | MET (0.79) | METKDRAXLRETKIT | |
| SCHEMBL372310 | 0.97 | MET (0.75) | METKDRAXLRETKIT | |
| SCHEMBL29693447 | 0.97 | MET (0.75) | METKDRAXLRETKIT | |
| SCHEMBL371806 | 0.96 | MET (0.81) | METKDRAXLRETKIT | |
| SCHEMBL371980 | 0.96 | MET (0.81) | METKDRAXLRETKIT | |
| SCHEMBL29693432 | 0.96 | MET (0.81) | METKDRAXLRETKIT | |
| SCHEMBL29693437 | 0.96 | MET (0.81) | METKDRAXLRETKIT | |
| SCHEMBL24444600 | 0.95 | MET (0.71) | METKDRAXLRETKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | claimed |
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |