Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 13/20 | 0.69 |
| ▸ | MERTK | Q12866 | 7/20 | 0.69 |
| ▸ | MET | P08581 | 14/20 | 0.62 |
| ▸ | KDR | P35968 | 6/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
| ▸ | HCK | P08631 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | BCR | P11274 | 2/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | FLT1 | P17948 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371542 | 1.00 | AXL (0.69) | AXLMERTKMETKDRAURKA | |
| SCHEMBL22566543 | 0.94 | MET (0.65) | AXLMERTKMETKDRAURKA | |
| SCHEMBL10449247 | 0.93 | MET (0.69) | AXLMERTKMETKDRAURKA | |
| SCHEMBL29693565 | 0.92 | AXL (0.56) | AXLMERTKMETKDRAURKA | |
| SCHEMBL371852 | 0.92 | AXL (0.56) | AXLMERTKMETKDRAURKA | |
| SCHEMBL372418 | 0.91 | AXL (0.70) | AXLMERTKMETKDRAURKA | |
| SCHEMBL29693425 | 0.89 | MET (0.77) | AXLMERTKMETKDRAURKA | |
| SCHEMBL4398401 | 0.89 | MET (0.77) | AXLMERTKMETKDRAURKA | |
| SCHEMBL372085 | 0.89 | MET (0.77) | AXLMERTKMETKDRAURKA | |
| SCHEMBL371819 | 0.88 | AXL (0.87) | AXLMERTKMETKDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | claimed |