Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 15/20 | 0.63 |
| ▸ | AXL | P30530 | 5/20 | 0.63 |
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | FLT3 | P36888 | 3/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | FER | P16591 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.59 |
| ▸ | MERTK | Q12866 | 1/20 | 0.59 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407651 | 1.00 | PDGFRA (0.64) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL371919 | 0.88 | PDGFRA (0.66) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL19373219 | 0.87 | PDGFRA (0.69) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL2744790 | 0.87 | PDGFRA (0.69) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL371539 | 0.85 | MET (0.70) | PDGFRAMETAXLKDRAURKA | |
| SCHEMBL20525878 | 0.85 | PDGFRA (0.47) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL5056203 | 0.85 | PDGFRA (0.72) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL3113049 | 0.84 | PDGFRA (0.71) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL4401175 | 0.82 | MET (0.76) | PDGFRAMETAXLKDRFLT3 | |
| SCHEMBL14971061 | 0.82 | AXL (0.59) | PDGFRAMETAXLKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |