Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 11/20 | 0.61 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | CTSA | P10619 | 4/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24501039 | 1.00 | POLQ (0.61) | POLQDHODHCTSAGPBAR1HTR5A | |
| SCHEMBL29695040 | 1.00 | POLQ (0.61) | POLQDHODHCTSAGPBAR1HTR5A | |
| SCHEMBL30526591 | 0.91 | POLQ (0.52) | POLQDHODH | |
| SCHEMBL30640062 | 0.89 | POLQ (0.60) | POLQHTR5A | |
| SCHEMBL30526637 | 0.89 | POLQ (0.63) | POLQCTSAGPBAR1 | |
| SCHEMBL30640087 | 0.89 | POLQ (0.60) | POLQHTR5A | |
| SCHEMBL30640089 | 0.89 | POLQ (0.60) | POLQHTR5A | |
| SCHEMBL25306864 | 0.89 | POLQ (0.63) | POLQCTSAGPBAR1 | |
| SCHEMBL30526594 | 0.87 | POLQ (0.49) | POLQ | |
| SCHEMBL24501117 | 0.87 | POLQ (0.50) | POLQDHODHCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024245310-A1 | THIAZOLYL OR THIADIAZOLYL AMIDES DERIVATIVES AND USE THEREOF | NINGBO NEWBAY TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2024-12-05 | — | — | WO | disclosed |
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |
| EP-4255573-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |