Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 5/20 | 0.60 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 8/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30640087 | 1.00 | POLQ (0.60) | POLQHTR5ACSF1RJAK2JAK1 | |
| SCHEMBL30640062 | 1.00 | POLQ (0.60) | POLQHTR5ACSF1RJAK2JAK1 | |
| SCHEMBL24501039 | 0.89 | POLQ (0.61) | POLQHTR5A | |
| SCHEMBL29695040 | 0.89 | POLQ (0.61) | POLQHTR5A | |
| SCHEMBL29694673 | 0.89 | POLQ (0.61) | POLQHTR5A | |
| SCHEMBL30526637 | 0.88 | POLQ (0.63) | POLQ | |
| SCHEMBL25306864 | 0.88 | POLQ (0.63) | POLQ | |
| SCHEMBL30526675 | 0.81 | JAK1 (0.47) | POLQCSF1RJAK2JAK1TYK2 | |
| SCHEMBL30905067 | 0.81 | POLQ (0.48) | POLQCSF1R | |
| SCHEMBL22731850 | 0.81 | POLQ (0.58) | POLQCSF1RJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |