Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708832 | 1.00 | TNKS2 (0.49) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL31667419 | 1.00 | TNKS2 (0.49) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL19573960 | 1.00 | TNKS2 (0.49) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL19573959 | 1.00 | TNKS2 (0.49) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL20012844 | 0.88 | TNKS2 (0.42) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL29031895 | 0.80 | MAPT (0.41) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL15256932 | 0.79 | TNKS2 (0.46) | TNKS2HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL8293271 | 0.78 | TSHR (0.48) | TNKS2HTR2BPBRM1TSHRHSD17B10 | |
| SCHEMBL12219994 | 0.76 | MKNK2 (0.40) | TSHRHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL17797168 | 0.75 | HSD17B10 (0.49) | TNKS2HTR2AHTR2CHTR2BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3606921-B1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. | INVENTIVA (FR) | 2022-06-01 | — | — | EP | claimed |