Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13847518 | 0.80 | CREBBP (0.55) | TSHRGSK3BTNKS2PBRM1LMNA | |
| SCHEMBL19573959 | 0.78 | TNKS2 (0.49) | TSHRGSK3BKMT2ATNKS2PBRM1 | |
| SCHEMBL19573960 | 0.78 | TNKS2 (0.49) | TSHRGSK3BKMT2ATNKS2PBRM1 | |
| SCHEMBL31667419 | 0.78 | TNKS2 (0.49) | TSHRGSK3BKMT2ATNKS2PBRM1 | |
| SCHEMBL29695366 | 0.78 | TNKS2 (0.49) | TSHRGSK3BKMT2ATNKS2PBRM1 | |
| SCHEMBL1708832 | 0.78 | TNKS2 (0.49) | TSHRGSK3BKMT2ATNKS2PBRM1 | |
| SCHEMBL677629 | 0.76 | MEN1 (0.55) | MEN1KMT2AS100A4POLBLMNA | |
| SCHEMBL22011499 | 0.74 | GSK3B (0.46) | TSHRGSK3BMEN1KMT2AS100A4 | |
| SCHEMBL12646072 | 0.74 | MEN1 (0.52) | MEN1KMT2AS100A4POLBLMNA | |
| SCHEMBL5063195 | 0.72 | BRPF1 (0.67) | TSHRGSK3BKMT2APOLBTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332912-A1 | Heteroarylaminosulfonylphenylderivates for use as sodium or calcium channel blockers in the treatment of pain | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-15 | — | — | EP | disclosed |
| EP-2327701-A1 | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2005013914-A2 | HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-02-17 | — | — | WO | disclosed |