Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10896632 | 0.83 | — | — | |
| SCHEMBL3787125 | 0.78 | — | — | |
| SCHEMBL1984184 | 0.78 | — | — | |
| SCHEMBL15867579 | 0.78 | — | — | |
| SCHEMBL14691575 | 0.78 | — | — | |
| SCHEMBL22624 | 0.78 | — | — | |
| SCHEMBL13676443 | 0.77 | — | — | |
| Ethylene SCHEMBL12984324 | 0.75 | — | — | |
| SCHEMBL20537347 | 0.75 | TSHR (0.35) | TSHRALDH1A1 | |
| Bicarbonate SCHEMBL15173574 | 0.75 | TP53 (0.40) | TSHRALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840539-B2 | Substituted pyrrolo,-furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2023-12-12 | — | — | US | claimed |
| US-11091500-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-17 | — | — | US | claimed |
| US-20210155633-A1 | Substituted Pyrrolo,-Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2021-05-27 | — | — | US | claimed |
| US-10947246-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-03-16 | — | — | US | claimed |
| US-10676483-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-06-09 | — | — | US | claimed |
| EP-2310014-B1 | TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | UNIV HOLY GHOST DUQUESNE (US) | 2020-03-18 | — | — | EP | claimed |
| US-10577377-B2 | Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-03-03 | — | — | US | claimed |
| US-20200017521-A1 | TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-01-16 | — | — | US | claimed |
| US-10464944-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-11-05 | — | — | US | claimed |
| US-10414777-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and method of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-09-17 | — | — | US | claimed |
| US-20100010016-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2010-01-14 | — | — | US | claimed |
| WO-2010006025-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-01-14 | — | — | WO | claimed |
| WO-2010006032-A1 | TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2010-01-14 | — | — | WO | claimed |
| US-20090082374-A1 | TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2009-03-26 | — | — | US | claimed |
| US-7482105-B2 | Toner for electrostatic latent image development and manufacturing method of the toner for electrostatic latent image development | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2009-01-27 | — | — | US | claimed |
| US-20050069802-A1 | Toner for electrostatic latent image development and manufacturing method of the toner for electrostatic latent image development | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2005-03-31 | — | — | US | claimed |
| US-6617483-B1 | Extractive distillation for separating a mixture of hydrocarbons with an alkylene glycol and a compatibility agent having polar parameters and hydrogen bonding parameters that result in improved separation | GAYLORD CHEMICAL CORPORATION | 2003-09-09 | — | — | US | claimed |
| EP-0787750-B1 | Poly(alkylethylene) structural isomers | BOREALIS GMBH (AT) | 2003-05-14 | — | — | EP | claimed |
| US-4695673-A | Process for the production of acylated 1,3-dicarbonyl compounds | STAUFFER CHEMICAL COMPANY (US) | 1987-09-22 | — | — | US | claimed |
| US-4401571-A | AMINE CURED EPOXY WITH RESIN FOAM FORMED IN SITU | NEY KARL F (AT) | 1983-08-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082374-A1 | TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | ABCG2, ABCC1, ABCB1 | TSHR 4819/4885ALDH1A1 1890/4885LMNA 683/4885 |
| US-10577377-B2 | Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | ABCG2, ABCB1, ABCC1 | TSHR 4852/4885ALDH1A1 1540/4885LMNA 1175/4885 |
| US-20200017521-A1 | TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | PLK1, AURKC, TOP1 | TSHR 4447/4885ALDH1A1 2557/4885LMNA 894/4885 |
| US-10676483-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | PLK1, AURKC, TOP1 | TSHR 4447/4885ALDH1A1 2557/4885LMNA 894/4885 |
| US-20100010016-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | ABCC1, ABCB1, ABCG2 | TSHR 4859/4885ALDH1A1 1985/4885LMNA 533/4885 |
| US-11840539-B2 | Substituted pyrrolo,-furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | ABCB1, ABCC1, ABCG2 | TSHR 4829/4885ALDH1A1 1241/4885LMNA 2046/4885 |
| US-11091500-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | ABCC1, ABCB1, ABCG2 | TSHR 4803/4885ALDH1A1 2007/4885LMNA 803/4885 |
| US-10947246-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | ABCB1, ABCC1, ABCB11 | TSHR 4840/4885ALDH1A1 1251/4885LMNA 1894/4885 |
| US-10464944-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof | ABCC1, ABCG2, TP53 | TSHR 4784/4885ALDH1A1 2399/4885LMNA 617/4885 |
| US-20210155633-A1 | Substituted Pyrrolo,-Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | ABCB1, ABCC1, ABCG2 | TSHR 4829/4885ALDH1A1 1241/4885LMNA 2046/4885 |
| US-10414777-B2 | Tricyclic compounds having antimitotic and/or antitumor activity and method of use thereof | ABCG2, ABCC1, ABCB1 | TSHR 4793/4885ALDH1A1 1886/4885LMNA 785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.