Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.37 |
| ▸ | MAP3K6 | O95382 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24583515 | 1.00 | BTK (0.41) | BTKPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL29696777 | 0.84 | TNKS (0.44) | PDE4BPDE4DPDE4APDE4CHTR1A | |
| SCHEMBL25597965 | 0.84 | PDE4B (0.39) | PDE4BPDE4DPDE4APDE4CMAP3K5 | |
| SCHEMBL25221747 | 0.84 | TNKS (0.44) | PDE4BPDE4DPDE4APDE4CHTR1A | |
| SCHEMBL25273567 | 0.84 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CHTR1A | |
| SCHEMBL24583544 | 0.84 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CHTR1A | |
| SCHEMBL25273568 | 0.84 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CHTR1A | |
| SCHEMBL25597977 | 0.83 | PAK1 (0.42) | PDE4BPDE4DPDE4APDE4CMAP3K5 | |
| SCHEMBL25273423 | 0.82 | PDE4B (0.38) | PDE4BPDE4DPDE4APDE4CHTR1A | |
| SCHEMBL24583457 | 0.82 | DRD3 (0.43) | PDE4BPDE4DPDE4APDE4CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267553-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140520-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |