Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25221747 | 1.00 | TNKS (0.44) | TNKSDRD4HTR1ADRD2HTR2A | |
| SCHEMBL25597977 | 0.88 | PAK1 (0.42) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL29696916 | 0.88 | ATR (0.41) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL24583722 | 0.88 | ATR (0.41) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL24583950 | 0.86 | TNKS (0.44) | TNKSJAK1JAK3JAK2TYK2 | |
| SCHEMBL29696873 | 0.86 | TNKS (0.44) | TNKSJAK1JAK3JAK2TYK2 | |
| SCHEMBL25273325 | 0.86 | KIT (0.42) | JAK1JAK3JAK2TYK2PDE4B | |
| SCHEMBL25597965 | 0.86 | PDE4B (0.39) | DRD4HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL25273326 | 0.86 | KIT (0.42) | JAK1JAK3JAK2TYK2PDE4B | |
| SCHEMBL25273568 | 0.86 | PDE4B (0.41) | DRD4HTR1ADRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267553-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140520-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |