Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24583722 | 1.00 | ATR (0.41) | ATRBRD4SYKABCB11BRD2 | |
| SCHEMBL29696827 | 0.91 | CD38 (0.40) | ATRBRD4SYKABCB11BRD2 | |
| SCHEMBL24583842 | 0.91 | CD38 (0.40) | ATRBRD4SYKABCB11BRD2 | |
| SCHEMBL29696698 | 0.90 | AHR (0.47) | L3MBTL1DRD4AHRMEN1POLB | |
| SCHEMBL25273121 | 0.90 | AHR (0.47) | L3MBTL1DRD4AHRMEN1POLB | |
| SCHEMBL25273122 | 0.90 | AHR (0.47) | L3MBTL1DRD4AHRMEN1POLB | |
| SCHEMBL25221747 | 0.88 | TNKS (0.44) | DRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL29696777 | 0.88 | TNKS (0.44) | DRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL25273921 | 0.87 | PDE4B (0.42) | ATRBRD4SYKABCB11BRD2 | |
| SCHEMBL25220189 | 0.87 | PDE4B (0.42) | ATRBRD4SYKABCB11BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267553-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140520-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |