Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | EBP | Q15125 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296970 | 1.00 | SIGMAR1 (0.55) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL4024634 | 1.00 | SIGMAR1 (0.55) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL296048 | 1.00 | SIGMAR1 (0.55) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL4023892 | 0.88 | SIGMAR1 (0.64) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL4021409 | 0.86 | SIGMAR1 (0.68) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL23254095 | 0.81 | SIGMAR1 (0.55) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL10129057 | 0.78 | SIGMAR1 (0.69) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL22858956 | 0.78 | SIGMAR1 (0.69) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL9922437 | 0.78 | SIGMAR1 (0.69) | SIGMAR1EBPKDM4EALDH1A1TDP1 | |
| SCHEMBL10129761 | 0.78 | SIGMAR1 (0.69) | SIGMAR1EBPKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147104-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-1709965-A2 | Methods of treating cytokine mediate diseases | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2006-10-11 | — | — | EP | disclosed |
| US-6916814-B2 | Methods of treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |