SCHEMBL29697249

SCHEMBL29697249

Cc1n[nH]c2cc([N+](=O)[O-])ccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.51
MAPT P10636 6/20 0.50
ALDH1A1 P00352 6/20 0.50
TDP1 Q9NUW8 3/20 0.50
HPGD P15428 1/20 0.50
KDM4E B2RXH2 1/20 0.50
DAO P14920 1/20 0.50
CYP3A4 P08684 3/20 0.49
NOS1 P29475 2/20 0.49
LMNA P02545 2/20 0.49
ALOX15 P16050 1/20 0.49
GRIA1 P42261 1/20 0.49
GRIA2 P42262 1/20 0.49
GRIA3 P42263 1/20 0.49
GRIA4 P48058 1/20 0.49
NAMPT P43490 1/20 0.46
XDH P47989 1/20 0.46
TSHR P16473 1/20 0.46
POLB P06746 3/20 0.45
MAOB P27338 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL588431 1.00 PARP1 (0.51) PARP1MAPTALDH1A1TDP1HPGD
Sulfuric Acid SCHEMBL1405805 0.93 PARP1 (0.46) PARP1MAPTALDH1A1TDP1HPGD
SCHEMBL266008 0.87 MAPT (0.61) PARP1MAPTALDH1A1TDP1HPGD
SCHEMBL29672461 0.87 MAPT (0.61) PARP1MAPTALDH1A1TDP1HPGD
Quinoline SCHEMBL27606941 0.83 MAPT (0.46) MAPTALDH1A1HPGDKDM4ECYP3A4
SCHEMBL29431208 0.81 JAK2 (0.51) PARP1MAPTALDH1A1TDP1HPGD
SCHEMBL2931498 0.81 JAK2 (0.51) PARP1MAPTALDH1A1TDP1HPGD
SCHEMBL30833662 0.81 DAO (0.51) PARP1MAPTALDH1A1TDP1HPGD
SCHEMBL921416 0.81 DAO (0.51) PARP1MAPTALDH1A1TDP1HPGD
SCHEMBL445096 0.80 MAPT (0.50) PARP1MAPTALDH1A1TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4010080-A1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER Artios Pharma Limited (GB) 2022-06-15 EP disclosed