Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 7/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | CFTR | P13569 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372291 | 1.00 | KLKB1 (0.39) | KLKB1PIK3CDHDAC1CFTRADORA2A | |
| SCHEMBL2373116 | 0.80 | KDM4E (0.57) | KDM4EHPGD | |
| SCHEMBL29699246 | 0.80 | KDM4E (0.57) | KDM4EHPGD | |
| SCHEMBL27990005 | 0.75 | PTPN11 (0.31) | — | |
| SCHEMBL2373130 | 0.73 | CFTR (0.40) | PIK3CDHDAC1CFTRADORA2AADORA1 | |
| SCHEMBL2373061 | 0.73 | NAMPT (0.40) | KLKB1HDAC1CFTR | |
| SCHEMBL2372384 | 0.73 | HPGDS (0.40) | HDAC1CFTRADORA2A | |
| SCHEMBL2373143 | 0.71 | CFTR (0.39) | PIK3CDHDAC1CFTRADORA2A | |
| SCHEMBL2372314 | 0.71 | KMT2A (0.50) | HDAC1CFTRADORA2A | |
| SCHEMBL14784270 | 0.70 | CFTR (0.42) | CFTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |