Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 12/20 | 0.45 |
| ▸ | FPR2 | P25090 | 6/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372661 | 1.00 | CFTR (0.45) | CFTRFPR2ACVR1MMP1MMP3 | |
| SCHEMBL2373130 | 0.73 | CFTR (0.40) | CFTR | |
| SCHEMBL2372492 | 0.72 | CFTR (0.41) | CFTRACVR1 | |
| SCHEMBL14784270 | 0.72 | CFTR (0.42) | CFTR | |
| SCHEMBL2372296 | 0.71 | GAA (0.48) | CFTR | |
| SCHEMBL22791161 | 0.69 | CFTR (0.43) | CFTRACVR1 | |
| SCHEMBL2371638 | 0.69 | HDAC2 (0.50) | CFTR | |
| SCHEMBL2372314 | 0.69 | KMT2A (0.50) | CFTR | |
| SCHEMBL2372384 | 0.69 | HPGDS (0.40) | CFTR | |
| SCHEMBL11989202 | 0.69 | CFTR (0.42) | CFTRACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |