Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 9/20 | 0.66 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371919 | 1.00 | CFTR (0.66) | CFTRALPLABL1CNR1MRGPRX4 | |
| SCHEMBL23671475 | 0.94 | CFTR (0.59) | CFTRALPLABL1CNR1MRGPRX4 | |
| SCHEMBL2372275 | 0.90 | CFTR (0.57) | CFTRABL1MRGPRX4S1PR4 | |
| SCHEMBL29699295 | 0.90 | CFTR (0.57) | CFTRABL1MRGPRX4S1PR4 | |
| SCHEMBL2371637 | 0.86 | CFTR (0.64) | CFTRALPLCNR1HSP90AB1 | |
| SCHEMBL29699354 | 0.86 | CFTR (0.64) | CFTRALPLCNR1HSP90AB1 | |
| SCHEMBL27990279 | 0.80 | CFTR (0.55) | CFTRCNR1HSP90AB1 | |
| SCHEMBL29798093 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL2372654 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL29699242 | 0.79 | CFTR (1.00) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |