Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 12/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372275 | 1.00 | CFTR (0.57) | CFTRABL1MRGPRX4KDM4EALDH1A1 | |
| SCHEMBL2371919 | 0.90 | CFTR (0.66) | CFTRABL1MRGPRX4S1PR4 | |
| SCHEMBL29699256 | 0.90 | CFTR (0.66) | CFTRABL1MRGPRX4S1PR4 | |
| SCHEMBL11928232 | 0.87 | CFTR (0.54) | CFTRMRGPRX4 | |
| SCHEMBL2372324 | 0.85 | CFTR (0.47) | CFTRALDH1A1 | |
| SCHEMBL23671475 | 0.84 | CFTR (0.59) | CFTRABL1MRGPRX4 | |
| SCHEMBL27906132 | 0.80 | CFTR (0.45) | CFTRHTT | |
| SCHEMBL14816565 | 0.80 | CFTR (0.52) | CFTR | |
| SCHEMBL2372320 | 0.80 | CFTR (0.59) | CFTR | |
| SCHEMBL29699235 | 0.80 | CFTR (0.59) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |