SCHEMBL29699281

SCHEMBL29699281

COc1ccc(CNC(=O)c2cc(Cl)cc(N)c2Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.54
MDM2 Q00987 1/20 0.54
KLKB1 P03952 1/20 0.52
HPGD P15428 5/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
HSP90AA1 P07900 1/20 0.51
HSP90AB1 P08238 1/20 0.51
ALDH1A1 P00352 3/20 0.50
MAPT P10636 3/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
KDM4E B2RXH2 1/20 0.50
USP2 O75604 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
LMNA P02545 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7655088 0.86 TP53 (0.55) TP53MDM2KLKB1HPGDHSP90AA1
SCHEMBL7649475 0.86 TP53 (0.55) TP53MDM2KLKB1HPGDALDH1A1
SCHEMBL17241538 0.85 TP53 (0.56) TP53MDM2KLKB1HPGDL3MBTL1
SCHEMBL17241501 0.83 TP53 (0.52) TP53MDM2KLKB1HPGDL3MBTL1
SCHEMBL13744520 0.82 TP53 (0.59) TP53MDM2HPGDL3MBTL1ALDH1A1
SCHEMBL24458116 0.82 HSP90AA1 (0.48) TP53KLKB1HPGDL3MBTL1HSP90AA1
SCHEMBL17581348 0.78 HPGD (0.53) TP53KLKB1HPGDL3MBTL1HSP90AA1
SCHEMBL17241514 0.78 ALDH1A1 (0.51) TP53MDM2KLKB1HPGDL3MBTL1
SCHEMBL7655589 0.78 HPGD (0.74) TP53HPGDALDH1A1MAPTNPC1
SCHEMBL29433999 0.78 HPGD (0.74) TP53HPGDALDH1A1MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4247795-A1 GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF Deciphera Pharmaceuticals, LLC (US) 2023-09-27 EP disclosed
WO-2022109001-A1 GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF DECIPHERA PHARMACEUTICALS, LLC (US) 2022-05-27 WO disclosed