Sugi Predict

Sugi Predict / Compounds / SCHEMBL29699364

SCHEMBL29699364

SCHEMBL29699364

Clc1ccc(COc2c[nH]nn2)c2ccccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 2/20 0.38
▸ CYP2A6 P11509 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ NPC1 O15118 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ GPR84 Q9NQS5 5/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ CNR1 P21554 1/20 0.31
▸ CNR2 P34972 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23457572 1.00 CYP1A2 (0.38) CYP1A2CYP2A6KDM4EALDH1A1KMT2A
SCHEMBL23457472 0.74 CYP1A2 (0.42) CYP1A2CYP2A6KDM4EALDH1A1KMT2A
SCHEMBL29699379 0.74 CYP1A2 (0.42) CYP1A2CYP2A6KDM4EALDH1A1KMT2A
SCHEMBL23457494 0.72 CYP1A2 (0.37) CYP1A2CYP2A6KDM4EALDH1A1KMT2A
SCHEMBL29699550 0.71 NPC1 (0.56) ALDH1A1KMT2ANPC1MEN1MAPT
SCHEMBL23484560 0.70 HAO1 (0.46) MCL1
Formic Acid SCHEMBL22608641 0.67 HAO1 (0.43) KMT2AMCL1
SCHEMBL22608642 0.66 HAO1 (0.34) KDM4EKMT2AMAPTHPGDCNR1
SCHEMBL12539076 0.65 NR4A2 (0.41) CYP1A2CYP2A6KDM4EALDH1A1KMT2A
SCHEMBL23457614 0.64 CYP1A2 (0.41) CYP1A2CYP2A6KDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230089374-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-23 — — US disclosed
US-20230088214-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-23 — — US disclosed
US-20230079913-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2023-03-16 — — US disclosed
US-11384055-B2 Glycolate oxidase inhibitors for the treatment of disease BIOMARIN PHARMACEUTICAL INC. (US) 2022-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230079913-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT CYP1A2 445/4885CYP2A6 672/4885KDM4E 3645/4885
US-20230088214-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT CYP1A2 463/4885CYP2A6 685/4885KDM4E 3325/4885
US-11384055-B2 Glycolate oxidase inhibitors for the treatment of disease XDH, PNPO, AGXT CYP1A2 445/4885CYP2A6 672/4885KDM4E 3645/4885
US-20230089374-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE XDH, PNPO, AGXT CYP1A2 445/4885CYP2A6 672/4885KDM4E 3645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.