Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 18/20 | 0.42 |
| ▸ | KDR | P35968 | 18/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 17/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.42 |
| ▸ | FLT1 | P17948 | 7/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100427 | 0.79 | LRRK2 (0.50) | KDRLRRK2 | |
| SCHEMBL29702360 | 0.79 | LRRK2 (0.50) | KDRLRRK2 | |
| SCHEMBL30544702 | 0.77 | PDE4D (0.44) | EPHA2KDREPHB4ERBB2LRRK2 | |
| SCHEMBL29702221 | 0.73 | LRRK2 (0.48) | KDRLRRK2 | |
| SCHEMBL25213735 | 0.69 | LRRK2 (0.47) | KDRLRRK2 | |
| SCHEMBL31083319 | 0.69 | LRRK2 (0.44) | KDRLRRK2 | |
| SCHEMBL29380274 | 0.69 | LRRK2 (0.47) | KDRLRRK2 | |
| SCHEMBL17076663 | 0.69 | LRRK2 (0.47) | KDRLRRK2 | |
| SCHEMBL25419464 | 0.67 | LRRK2 (0.45) | KDRLRRK2 | |
| SCHEMBL8596166 | 0.63 | PDE10A (0.41) | KDRLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621186-A | Heterocyclic compounds as modulators of RAS signaling pathway | 上海维申医药有限公司 | 2022-06-14 | — | — | CN | disclosed |