Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25213735 | 1.00 | LRRK2 (0.47) | LRRK2AXLMEN1KMT2AL3MBTL1 | |
| SCHEMBL31083319 | 0.94 | LRRK2 (0.44) | LRRK2AXLMEN1KMT2AL3MBTL1 | |
| SCHEMBL29702360 | 0.87 | LRRK2 (0.50) | LRRK2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL26100427 | 0.87 | LRRK2 (0.50) | LRRK2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL17076663 | 0.82 | LRRK2 (0.47) | LRRK2L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL29702221 | 0.81 | LRRK2 (0.48) | LRRK2ALDH1A1HTTGAAKDM4E | |
| SCHEMBL25419464 | 0.79 | LRRK2 (0.45) | LRRK2ALDH1A1HTTGAAKDM4E | |
| SCHEMBL31083161 | 0.79 | LRRK2 (0.39) | LRRK2KMT2AALDH1A1HTTGAA | |
| SCHEMBL17868785 | 0.78 | AXL (0.46) | AXLMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL29702191 | 0.75 | BRD4 (0.47) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192454-A1 | COMPOSITIONS FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022031838-A1 | COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |
| WO-2022031998-A2 | PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE PREPARATION OF COMPOUNDS THAT MODULATE SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |