Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.43 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.43 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.43 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413256 | 0.83 | ROCK2 (0.52) | ROCK1ROCK2PRKG1PKN2LRRK2 | |
| SCHEMBL30544659 | 0.81 | ACACB (0.38) | LRRK2GRM4 | |
| SCHEMBL29702357 | 0.79 | ROCK1 (0.66) | ROCK1ROCK2PRKCDPRKACAPRKG1 | |
| SCHEMBL30544671 | 0.78 | PDE4D (0.45) | PDE4B | |
| SCHEMBL29058957 | 0.78 | PDE4D (0.45) | PDE4B | |
| SCHEMBL29058960 | 0.78 | PDE4D (0.45) | PDE4B | |
| SCHEMBL29702396 | 0.76 | ALK (0.41) | ALKLRRK2 | |
| SCHEMBL5409080 | 0.75 | ROCK2 (0.57) | ROCK1ROCK2PRKG1PKN2LRRK2 | |
| SCHEMBL6584281 | 0.73 | PDE4D (0.52) | ALDH1A1PDE4BHSD17B10 | |
| SCHEMBL1009542 | 0.71 | HSD17B10 (0.51) | ROCK2ALDH1A1PARP1PRKCIPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116635371-A | Polycyclic pyridazinone derivative serving as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-114621186-A | Heterocyclic compounds as modulators of RAS signaling pathway | 上海维申医药有限公司 | 2022-06-14 | — | — | CN | disclosed |