Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.58 |
| ▸ | OGFRL1 | Q5TC84 | 8/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | CFTR | P13569 | 5/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ARRB1 | P49407 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723407 | 0.94 | OPRM1 (0.64) | OPRM1OGFRL1OPRL1CFTROPRD1 | |
| SCHEMBL2976864 | 0.93 | OPRM1 (0.52) | OPRM1OGFRL1OPRL1CFTROPRD1 | |
| SCHEMBL4763223 | 0.88 | OPRM1 (0.51) | OPRM1OGFRL1OPRL1CFTRMEN1 | |
| SCHEMBL4766511 | 0.88 | OPRM1 (0.51) | OPRM1OGFRL1OPRL1CFTRKMT2A | |
| SCHEMBL2977418 | 0.87 | CFTR (0.49) | OPRM1OGFRL1CFTR | |
| SCHEMBL4763423 | 0.87 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1CFTROPRD1 | |
| Citric Acid SCHEMBL2975179 | 0.86 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1CFTROPRD1 | |
| Citric Acid SCHEMBL2976541 | 0.84 | OPRM1 (0.45) | OPRM1OGFRL1OPRL1CFTROPRD1 | |
| SCHEMBL2977285 | 0.83 | OPRM1 (0.60) | OPRM1OGFRL1OPRL1CFTROPRD1 | |
| SCHEMBL4724252 | 0.82 | OPRM1 (0.50) | OPRM1OGFRL1OPRL1CFTROPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778680-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2008-10-08 | — | — | EP | claimed |
| US-7776848-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-7776848-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-7776848-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| EP-1778680-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2008-10-08 | — | — | EP | disclosed |
| US-20070213351-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213351-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213351-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213351-A1 | Spirocyclic cyclohexane compounds | PKD1, PKD2, NR3C2 | OPRM1 768/4885OGFRL1 1860/4885OPRL1 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.