SCHEMBL29704459

SCHEMBL29704459

CNC(=O)c1ccc2cccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CREBBP Q92793 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19644417 1.00 CREBBP (1.00) CREBBP
SCHEMBL19657782 0.91 CREBBP (0.83) CREBBP
SCHEMBL25094215 0.87 CREBBP (0.77) CREBBP
SCHEMBL19657710 0.85 CREBBP (0.74) CREBBP
SCHEMBL23956790 0.83 CREBBP (0.71) CREBBP
SCHEMBL30292117 0.82 CREBBP (0.70) CREBBP
SCHEMBL25093848 0.82 CREBBP (0.70) CREBBP
SCHEMBL19657928 0.81 CREBBP (0.91) CREBBP
SCHEMBL25093970 0.80 CREBBP (0.67) CREBBP
SCHEMBL29704510 0.80 CREBBP (1.00) CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115028617-A Heterocyclic inhibitors of CBP/EP300 and their use in the treatment of cancer 基因泰克公司 2022-09-09 — — CN disclosed
CN-109476641-B Heterocyclic inhibitors of CBP/EP300 and their use in the treatment of cancer 基因泰克公司 2022-07-05 — — CN disclosed
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