Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20522214 | 1.00 | LMNA (0.42) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL29705130 | 0.91 | CYP1A2 (0.42) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL20556271 | 0.91 | CYP1A2 (0.42) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL20521839 | 0.87 | LMNA (0.50) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL29705211 | 0.87 | LMNA (0.50) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL20520935 | 0.86 | LMNA (0.41) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL29705104 | 0.85 | LMNA (0.36) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL20521317 | 0.85 | LMNA (0.36) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL20521025 | 0.83 | BAZ2B (0.44) | LMNAKMT2APOLBTDP1KDM4E | |
| SCHEMBL29705174 | 0.83 | BAZ2B (0.44) | LMNAKMT2APOLBTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |