Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20520988 | 1.00 | LMNA (0.53) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL3696586 | 0.88 | LMNA (0.64) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL20521434 | 0.85 | LMNA (0.41) | LMNATSHRMAPTKMT2AALDH1A1 | |
| SCHEMBL3693779 | 0.85 | LMNA (0.55) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL20257904 | 0.84 | LMNA (0.49) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL20243507 | 0.83 | LMNA (0.53) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL20240764 | 0.82 | LMNA (0.48) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL3695562 | 0.82 | LMNA (0.52) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL21815626 | 0.82 | LMNA (0.53) | LMNAGABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL20520979 | 0.81 | LMNA (0.47) | LMNAGABRA1GABRB1GABRA3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |