Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366568 | 1.00 | AKR1C4 (0.47) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL29851193 | 0.91 | AKR1C4 (0.47) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL590353 | 0.91 | AKR1C4 (0.47) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL24697741 | 0.88 | KEAP1 (0.45) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL2371182 | 0.86 | LCK (0.48) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL31430795 | 0.86 | SMN1; SMN2 (0.48) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL6860298 | 0.86 | SMN1; SMN2 (0.48) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL5872835 | 0.83 | KDM4E (0.52) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL24760837 | 0.83 | AKR1C2 (0.48) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL1976832 | 0.83 | CA1 (0.45) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184679-A | Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material | 中国石油天然气股份有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-118184679-A | Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material | 中国石油天然气股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-116157392-A | Compounds targeting RNA binding proteins or RNA modification proteins | 雷多纳治疗公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-111825656-B | Inhibitors of protein arginine methyltransferase 5 (PRMT 5), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-110431139-B | Deuterated imidazo [4,5-c ] quinolin-2-one compounds and their use in treating cancer | 阿斯利康(瑞典)有限公司 | 2022-07-05 | — | — | CN | disclosed |