Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | PAK4 | O96013 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 2/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22282069 | 1.00 | HPGDS (0.61) | HPGDSHTR2APLK4PAK4HTR2C | |
| SCHEMBL22281549 | 0.98 | HPGDS (0.60) | HPGDSHTR2APLK4PAK4HTR2C | |
| SCHEMBL3754341 | 0.94 | HPGDS (0.53) | HPGDSHTR2APLK4PAK4HTR2C | |
| Hydrochloric Acid SCHEMBL22497004 | 0.85 | PLK4 (0.47) | HPGDSHTR2APLK4PAK4HTR2C | |
| Hydrochloric Acid SCHEMBL22497005 | 0.85 | PLK4 (0.47) | HPGDSHTR2APLK4PAK4HTR2C | |
| SCHEMBL3755112 | 0.83 | PLK4 (0.43) | HPGDSPLK4PAK4PDE2APAK1 | |
| SCHEMBL3755106 | 0.83 | PLK4 (0.43) | HPGDSPLK4PAK4PDE2APAK1 | |
| SCHEMBL8293780 | 0.81 | HPGDS (0.60) | HPGDSHTR2APLK4PAK4HTR2C | |
| SCHEMBL28610635 | 0.80 | BTK (0.53) | PAK1 | |
| SCHEMBL28610634 | 0.80 | BTK (0.53) | PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368677-A1 | CD73 INHIBITORS | ORIC PHARMACEUTICALS INC (US) | 2025-12-04 | — | — | US | disclosed |
| CN-119371459-A | Compound and application thereof | 重庆医药工业研究院有限责任公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-117642411-A | Small molecule CD73 antagonists and uses thereof | 西藏海思科制药有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-11807658-B2 | CD73 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20220220147-A1 | CD73 INHIBITORS | ORIC PHARMACEUTICALS, INC. | 2022-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11807658-B2 | CD73 inhibitors | ENTPD5, NT5E, ENTPD1 | HPGDS 1452/4885HTR2A 1124/4885PLK4 3744/4885 |
| US-20220220147-A1 | CD73 INHIBITORS | ENTPD5, NT5E, ENTPD1 | HPGDS 1452/4885HTR2A 1124/4885PLK4 3744/4885 |
| US-20250368677-A1 | CD73 INHIBITORS | ENTPD5, NT5E, ENTPD1 | HPGDS 1452/4885HTR2A 1124/4885PLK4 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.