Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.61 |
| ▸ | DPP4 | P27487 | 9/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271402 | 1.00 | PREP (0.61) | PREPDPP4GAACTSKNFKB1 | |
| SCHEMBL8272077 | 1.00 | PREP (0.61) | PREPDPP4GAACTSKNFKB1 | |
| SCHEMBL6062491 | 0.81 | PREP (0.64) | PREPDPP4 | |
| SCHEMBL6063678 | 0.81 | PREP (0.64) | PREPDPP4 | |
| SCHEMBL6062493 | 0.81 | PREP (0.64) | PREPDPP4 | |
| SCHEMBL2981812 | 0.81 | PREP (0.41) | PREPGAANFKB1NFKB2RELA | |
| SCHEMBL8294395 | 0.81 | PREP (0.41) | PREPGAANFKB1NFKB2RELA | |
| SCHEMBL6062213 | 0.81 | PREP (0.43) | PREPGAANFKB1NFKB2RELA | |
| SCHEMBL6063342 | 0.81 | PREP (0.43) | PREPGAANFKB1NFKB2RELA | |
| SCHEMBL6062416 | 0.81 | PREP (0.43) | PREPGAANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786163-B2 | Constrained cyano compounds | Forest Laboratories Holdings Limited (BM) | 2010-08-31 | — | — | US | disclosed |
| EP-1778220-A1 | CONSTRAINED CYANO COMPOUNDS | Phenomix Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006017292-A1 | CONSTRAINED CYANO COMPOUNDS | PHENOMIX CORPORATION (US) | 2006-02-16 | — | — | WO | disclosed |
| US-20060009518-A1 | Constrained cyano compounds | Forest Laboratories Holding Limited (BM) | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009518-A1 | Constrained cyano compounds | DNPEP, PREP, PEPD | PREP 2/4885DPP4 9/4885GAA 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.