Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465431 | 0.87 | KDM4E (0.50) | KDM4EALDH1A1POLBGAATDP1 | |
| SCHEMBL29707485 | 0.81 | NR4A2 (0.47) | KDM4EALDH1A1GAAL3MBTL1EZH2 | |
| SCHEMBL27030475 | 0.81 | NR4A2 (0.47) | KDM4EALDH1A1GAAL3MBTL1EZH2 | |
| SCHEMBL19179903 | 0.77 | AKR1C3 (0.44) | KDM4EALDH1A1POLBGAATDP1 | |
| SCHEMBL14279689 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1POLBGAATDP1 | |
| SCHEMBL16115819 | 0.76 | DHODH (0.44) | KDM4EALDH1A1DHODHAKR1C3AKR1C2 | |
| SCHEMBL18878243 | 0.74 | MEN1 (0.62) | KDM4EALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL30020580 | 0.74 | PBRM1 (0.54) | KDM4EALDH1A1POLBGAATDP1 | |
| SCHEMBL6175041 | 0.74 | PBRM1 (0.54) | KDM4EALDH1A1POLBGAATDP1 | |
| SCHEMBL706591 | 0.74 | PDE3B (0.43) | KDM4EALDH1A1GAAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621191-B | EZH2 inhibitor and preparation and application thereof | 东南大学 | 2023-08-15 | — | — | CN | disclosed |
| CN-114621191-A | EZH2 inhibitor and preparation and application thereof | 东南大学 | 2022-06-14 | — | — | CN | disclosed |