Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27030475 | 1.00 | NR4A2 (0.47) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL2797608 | 0.82 | KDM4E (0.51) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL29707481 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1EZH2L3MBTL1GAA | |
| SCHEMBL17433459 | 0.80 | NR4A2 (0.50) | NR4A2CHEK1MAPTALDH1A1KIF11 | |
| SCHEMBL18851498 | 0.79 | NR4A2 (0.49) | NR4A2CHEK1KDM4EMAPTALDH1A1 | |
| SCHEMBL1868464 | 0.79 | NR4A2 (0.52) | NR4A2CHEK1ALDH1A1CREBBPL3MBTL1 | |
| SCHEMBL30908476 | 0.78 | NR4A2 (0.64) | NR4A2KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL18851180 | 0.78 | NR4A2 (0.48) | NR4A2CHEK1MAPTALDH1A1KIF11 | |
| SCHEMBL1133930 | 0.77 | NR4A2 (0.51) | NR4A2CHEK1METGSK3BLIMK1 | |
| SCHEMBL1196820 | 0.77 | NR4A2 (0.65) | NR4A2CHEK1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308564-A1 | POLYCYCLIC INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-114621191-B | EZH2 inhibitor and preparation and application thereof | 东南大学 | 2023-08-15 | — | — | CN | disclosed |
| WO-2022197789-A1 | POLYCYCLIC INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| CN-114621191-A | EZH2 inhibitor and preparation and application thereof | 东南大学 | 2022-06-14 | — | — | CN | disclosed |