Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 4/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.42 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16337414 | 1.00 | HCAR1 (0.55) | HCAR1BTKOPRM1OGFRL1OPRD1 | |
| SCHEMBL16335107 | 1.00 | HCAR1 (0.55) | HCAR1BTKOPRM1OGFRL1OPRD1 | |
| SCHEMBL19118890 | 0.86 | HCAR1 (0.52) | HCAR1EGFRSRCHPGDSJAK2 | |
| SCHEMBL19118889 | 0.86 | HCAR1 (0.52) | HCAR1EGFRSRCHPGDSJAK2 | |
| SCHEMBL16336882 | 0.86 | HCAR1 (0.54) | HCAR1BTKHPGDSJAK2JAK1 | |
| SCHEMBL16333786 | 0.86 | HCAR1 (0.54) | HCAR1BTKHPGDSJAK2JAK1 | |
| SCHEMBL19118355 | 0.84 | HCAR1 (0.49) | HCAR1JAK2JAK1FPR2MAPT | |
| SCHEMBL19118356 | 0.84 | HCAR1 (0.49) | HCAR1JAK2JAK1FPR2MAPT | |
| SCHEMBL16333958 | 0.84 | BTK (0.54) | BTKJAK2JAK1ACVR1MAPT | |
| SCHEMBL31032266 | 0.79 | HCAR1 (0.49) | HCAR1EGFRSRCHPGDSJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008328-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | AbbVie Inc. (US) | 2022-06-08 | — | — | EP | disclosed |