Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9983255 | 1.00 | BTK (0.52) | BTKJAK2POLBMEN1KMT2A | |
| SCHEMBL13893967 | 0.88 | BTK (0.47) | BTKJAK2POLBMEN1KMT2A | |
| SCHEMBL149181 | 0.86 | BTK (0.50) | BTKJAK2POLB | |
| SCHEMBL12070562 | 0.86 | BTK (0.50) | BTKJAK2POLB | |
| SCHEMBL29709471 | 0.86 | BTK (0.50) | BTKJAK2POLB | |
| SCHEMBL708646 | 0.84 | BTK (0.49) | BTKJAK2POLBMEN1KMT2A | |
| SCHEMBL9983905 | 0.84 | BTK (0.59) | BTKJAK2POLB | |
| SCHEMBL12070563 | 0.82 | BTK (0.50) | BTKJAK2KMT2ARAB9ANPC1 | |
| SCHEMBL14860170 | 0.79 | JAK2 (0.61) | BTKJAK2POLBMEN1KMT2A | |
| SCHEMBL122995 | 0.75 | MEN1 (0.56) | BTKJAK2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115368362-A | Quinoxalinone derivatives as BTK inhibitors and application thereof | 华东理工大学 | 2022-11-22 | — | — | CN | disclosed |
| CN-110511209-B | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2022-07-05 | — | — | CN | disclosed |
| EP-4008328-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | AbbVie Inc. (US) | 2022-06-08 | — | — | EP | disclosed |