Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | DDT | P30046 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22914931 | 1.00 | MAPT (0.48) | MAPTUSP2HDAC8GAALMNA | |
| SCHEMBL22914920 | 0.88 | MAPT (0.50) | MAPTUSP2HDAC8GAALMNA | |
| SCHEMBL29709838 | 0.88 | MAPT (0.50) | MAPTUSP2HDAC8GAALMNA | |
| SCHEMBL22914939 | 0.87 | MAPT (0.48) | MAPTUSP2HDAC8GAALMNA | |
| SCHEMBL22914924 | 0.87 | MAPT (0.50) | MAPTUSP2HDAC8GAALMNA | |
| SCHEMBL29709825 | 0.87 | MAPT (0.50) | MAPTUSP2HDAC8GAALMNA | |
| SCHEMBL22914919 | 0.83 | DDT (0.50) | MAPTUSP2GAALMNAPOLB | |
| SCHEMBL29709845 | 0.83 | DDT (0.50) | MAPTUSP2GAALMNAPOLB | |
| SCHEMBL22914935 | 0.81 | MAPT (0.51) | MAPTUSP2GAALMNAPOLB | |
| SCHEMBL22914930 | 0.81 | MAPT (0.51) | MAPTUSP2GAALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003009-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | Oregon Health & Science University (US) | 2022-06-01 | — | — | EP | disclosed |