Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | DDT | P30046 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29709808 | 0.87 | MAPT (0.48) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL22914931 | 0.87 | MAPT (0.48) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL29709838 | 0.84 | MAPT (0.50) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL22914920 | 0.84 | MAPT (0.50) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL22914919 | 0.83 | DDT (0.50) | MAPTGAAUSP2LMNAPOLB | |
| SCHEMBL29709845 | 0.83 | DDT (0.50) | MAPTGAAUSP2LMNAPOLB | |
| SCHEMBL29709825 | 0.83 | MAPT (0.50) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL22914924 | 0.83 | MAPT (0.50) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL22914928 | 0.82 | MAPT (0.47) | MAPTHDAC8GAAUSP2LMNA | |
| SCHEMBL29709912 | 0.82 | MAPT (0.47) | MAPTHDAC8GAAUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398110-B2 | Second generation inhibitors of mitochondrial permeability transition pore with improved plasma stability | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2025-08-26 | — | — | US | disclosed |
| US-20220289690-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2022-09-15 | — | — | US | disclosed |
| EP-4003009-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | Oregon Health & Science University (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289690-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | TIMM13, MTCH2, AFG3L2 | MAPT 2367/4885HDAC8 3158/4885GAA 4288/4885 |
| US-12398110-B2 | Second generation inhibitors of mitochondrial permeability transition pore with improved plasma stability | TIMM13, MTCH2, AFG3L2 | MAPT 2367/4885HDAC8 3158/4885GAA 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.