Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | ST6GAL1 | P15907 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.32 |
| ▸ | POLA1 | P09884 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29950242 | 0.86 | CYP3A4 (0.32) | CYP3A4TOP2AST6GAL1 | |
| SCHEMBL4971197 | 0.84 | PDE3A (0.41) | ST6GAL1POLBPDE4DPDE3ASLC29A1 | |
| SCHEMBL5201335 | 0.82 | TYMP (0.42) | CYP3A4ST6GAL1 | |
| SCHEMBL29720399 | 0.80 | ADORA1 (0.40) | — | |
| SCHEMBL5709959 | 0.76 | PDE3A (0.41) | POLBPDE4DPDE3ASLC29A1LMNA | |
| SCHEMBL22363161 | 0.75 | POLA1 (0.42) | POLBPDE4DPDE3ASLC29A1POLA1 | |
| SCHEMBL8627861 | 0.72 | PDE3A (0.44) | ST6GAL1POLBPDE4DPDE3ASLC29A1 | |
| SCHEMBL16401939 | 0.72 | TYMP (0.42) | — | |
| SCHEMBL19644955 | 0.72 | PDE4D (0.38) | TOP2APOLBPDE4DPDE3ASLC29A1 | |
| SCHEMBL5859677 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116656795-A | Nucleotide derivatives and methods of use thereof | 纽约哥伦比亚大学董事会 | 2023-08-29 | — | — | CN | disclosed |
| CN-114989235-A | Design and synthesis of nucleotides based on novel disulfide linkers for use as reversible terminators for DNA sequencing by synthesis | 哥伦比亚大学董事会 | 2022-09-02 | — | — | CN | disclosed |
| CN-108779138-B | Design and synthesis of nucleotides based on novel disulfide linkers for use as reversible terminators for DNA sequencing by synthesis | 哥伦比亚大学董事会 | 2022-06-17 | — | — | CN | disclosed |