Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26976753 | 1.00 | CHEK1 (0.48) | CHEK1CHEK2IRAK1IDO1TDO2 | |
| SCHEMBL29720649 | 0.95 | CHEK1 (0.51) | CHEK1CHEK2IDO1TDO2GPR119 | |
| SCHEMBL26976746 | 0.95 | CHEK1 (0.51) | CHEK1CHEK2IDO1TDO2GPR119 | |
| SCHEMBL26976771 | 0.91 | CHEK1 (0.52) | CHEK1CHEK2IRAK1IDO1TDO2 | |
| SCHEMBL26976725 | 0.90 | CHEK1 (0.45) | CHEK1CHEK2IRAK1IDO1TDO2 | |
| SCHEMBL26976711 | 0.89 | CHEK1 (0.44) | CHEK1CHEK2IRAK1IDO1TDO2 | |
| SCHEMBL26976814 | 0.88 | CHEK1 (0.54) | CHEK1CHEK2IRAK1IDO1TDO2 | |
| SCHEMBL617376 | 0.88 | CHEK1 (0.52) | CHEK1CHEK2IRAK1IDO1TDO2 | |
| SCHEMBL29720806 | 0.88 | ACKR3 (0.45) | CHEK1CHEK2IRAK1ACKR3KDM1A | |
| SCHEMBL26976832 | 0.88 | ACKR3 (0.45) | CHEK1CHEK2IRAK1ACKR3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4298095-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | Sperogenix Therapeutics Limited (HK) | 2024-01-03 | — | — | EP | disclosed |
| WO-2022162606-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | SPEROGENIX THERAPEUTICS LIMITED (CN) | 2022-08-04 | — | — | WO | disclosed |