Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 9/20 | 0.73 |
| ▸ | KCNQ3 | O43525 | 8/20 | 0.73 |
| ▸ | KCNQ4 | P56696 | 5/20 | 0.73 |
| ▸ | KCNQ5 | Q9NR82 | 5/20 | 0.73 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21501774 | 1.00 | KCNQ2 (0.73) | KCNQ2KCNQ3KCNQ4KCNQ5GNRHR | |
| SCHEMBL21501785 | 0.88 | KCNQ2 (0.80) | KCNQ2KCNQ3KCNQ4KCNQ5GNRHR | |
| SCHEMBL29721679 | 0.88 | KCNQ2 (0.80) | KCNQ2KCNQ3KCNQ4KCNQ5GNRHR | |
| SCHEMBL29721511 | 0.88 | KCNQ2 (0.80) | KCNQ2KCNQ3KCNQ4KCNQ5GNRHR | |
| SCHEMBL21501814 | 0.88 | KCNQ2 (0.80) | KCNQ2KCNQ3KCNQ4KCNQ5GNRHR | |
| SCHEMBL21501777 | 0.85 | KCNQ2 (0.74) | KCNQ2KCNQ3KCNQ4KCNQ5CCNE1 | |
| SCHEMBL29721508 | 0.85 | KCNQ2 (0.74) | KCNQ2KCNQ3KCNQ4KCNQ5CCNE1 | |
| SCHEMBL21496312 | 0.84 | KCNQ2 (0.52) | KCNQ2KCNQ3KCNQ4KCNQ5CYP2C9 | |
| SCHEMBL21501771 | 0.84 | KCNQ2 (0.75) | KCNQ2KCNQ3KCNQ4KCNQ5GPR35 | |
| SCHEMBL29721764 | 0.84 | KCNQ2 (0.75) | KCNQ2KCNQ3KCNQ4KCNQ5GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | KCNH3, KCNH2, KCNJ11 | KCNQ2 35/4885KCNQ3 43/4885KCNQ4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.